|
KMID : 0383419680090010127
|
|
Korean Modern Medical Journal
1968 Volume.9 No. 1 p.127 ~ p.135
|
|
|
Studies on Hemodynamic Effects of Vasoconstrictor and Vasodilatro
|
|
|
|
|
Abstract
|
|
|
Hemodynarnic effects of metaraminol, , a sympathornimetic agent, and phenoxybenzamine, an drenergic blocking agent, were studied in 30 mongrel dogs. In the metaraminol group, lmg./kg. 0 county; was given intramuscularly with concomitant intravenous infusion of 500 ml. of 5% glucose, and 92:4~in the phenoxybenzamine group, ling./kg. in 500 ml. of 5% glucose was administered W.: New intravenously. In both groups the intravenous infusions were given in 30 minutes and hemody-rub 1i namic measurements were made just prior to and after medication at 30 minutes interval for 120 mycu minutes.
The heart rate was significantly decreased in the metaraminol group, but it was slightly .increased at the end of infusion followed by a significant decrease in the phenoxybenzamine Epidern, group.
The stroke volume and cardiac index at the end of infusion showed no significant change in iensland,). the metaraminol group and marked increase in the phenoxybenzamine group. However, they were aclassified: considerably decreased thereafter in both groups.
The femoral artery mean pressure was markedly increased followed by a gradual decrease in the metaraminol group, whereas a significant fall with no initial rise was noted in the agnus, phenoxybenzamine group.
The total peripheral resistance was progressively increased in the metaraminol group but it was markedly decreased in the phenoxybenzamine group.
The venous pressure was markedly elevated at the end of infusion and then gradually decreased in either metaraminol or phenoxybenzamine groups. In both groups the venous pressure at the end of observation was, however, still considerably higher than it was prior to medication.
The pulmonary artery mean pressure was gradually decreased in both groups preceded by a significant rise at . the end of infusion.
The total pulmonary resistance was decreased in the phenoxybenzamine group but in i metaraminol group it was markedly elevated at the end of infusion followed by a slight decrea
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|